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Among 20 fraternal twin pairs discordant for the presence of e4,twins with the e4 allele demonstrated poorer mean performance than their co-twins without the e4 allele.This relationship was also noted cross-sectionally where age-and education-adjusted scores of 50 individual twin subjects with at least one e4 allele demonstrated poorer performance compared with 138 individual twins without an e4 allele.The apoE e4 allele may be associated with decreased cognitive function in discordant twin pairs.Our results suggest that e4 may represent a potential marker for accelerated cognitive aging and such individuals may be at greater risk for development of late-onset Alzheimer dementia or multi-infarct dementia. |
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